Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628625 | 0.88 | ALOX5 (0.78) | ALOX5L3MBTL1MAPTRAB9AKMT2A | |
| SCHEMBL9629268 | 0.87 | ALOX5 (0.77) | ALOX5L3MBTL1NPC1HPGDTRPM8 | |
| SCHEMBL9629413 | 0.86 | ALOX5 (0.75) | ALOX5L3MBTL1TRPM8 | |
| SCHEMBL9630604 | 0.84 | ALOX5 (0.72) | ALOX5L3MBTL1MEN1ALDH1A1KMT2A | |
| SCHEMBL9630227 | 0.82 | ALOX5 (1.00) | ALOX5L3MBTL1TRPM8 | |
| SCHEMBL9630562 | 0.79 | ALOX5 (0.66) | ALOX5L3MBTL1TRPM8 | |
| SCHEMBL7693031 | 0.73 | ALOX5 (0.57) | ALOX5NPC1HPGDMAPT | |
| SCHEMBL9629404 | 0.72 | TRPM8 (0.59) | ALOX5TRPM8 | |
| SCHEMBL1246771 | 0.69 | L3MBTL1 (0.71) | ALOX5L3MBTL1NPC1HPGDALDH1A1 | |
| SCHEMBL9835733 | 0.69 | ALOX5 (0.52) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |