Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.39 |
| ▸ | PPARD | Q03181 | 12/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627777 | 0.88 | PPARG (0.37) | PPARGPPARDFFAR1MTNR1AMTNR1B | |
| SCHEMBL9627910 | 0.78 | HTR1A (0.44) | HTR1AHTR2C | |
| SCHEMBL9628968 | 0.78 | HRH3 (0.35) | PPARGFFAR1PPARA | |
| SCHEMBL9406456 | 0.75 | HTR1D (0.44) | HTR1AHTR1D | |
| SCHEMBL9628089 | 0.75 | ACHE (0.41) | MTNR1AMTNR1B | |
| SCHEMBL9627868 | 0.73 | KMT2A (0.41) | PPARGPPARDFFAR1HTR1AHTR2C | |
| SCHEMBL9627835 | 0.73 | DRD3 (0.46) | — | |
| SCHEMBL9628391 | 0.73 | ALDH1A1 (0.41) | PPARGPPARDFFAR1PPARAHTR1A | |
| Oxalic Acid SCHEMBL9628990 | 0.73 | ACHE (0.39) | PPARGPPARDFFAR1MTNR1AMTNR1B | |
| SCHEMBL9628742 | 0.73 | TP53 (0.41) | PPARGPPARDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-B1 | 3-AMINOMETHYL DERIVATIVES OF INDANE, INDOLINE AND DIHYDROBENZOFURANE AND DIHYDROBENZOTHIOPHENE | H. LUNDBECK A/S (DK) | 1992-05-06 | — | — | EP | disclosed |
| US-4946863-A | CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith | H. LUNDBECK A/S (DK) | 1990-08-07 | — | — | US | disclosed |
| US-4847254-A | CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes | H. LUNDBECK A/S (DK) | 1989-07-11 | — | — | US | disclosed |
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |