Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754030 | 0.77 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL9754002 | 0.73 | ALOX5 (0.47) | ALOX5 | |
| SCHEMBL3681457 | 0.72 | TP53 (0.43) | ALOX5TP53MAPTSMN1; SMN2GCGR | |
| SCHEMBL7693026 | 0.71 | NPC1 (0.49) | ALOX5TP53MAPTSMN1; SMN2TLR8 | |
| SCHEMBL27744669 | 0.71 | DHFR (0.47) | ALOX5TP53MAPTSMN1; SMN2GCGR | |
| SCHEMBL27629514 | 0.71 | ALOX5 (0.50) | ALOX5TP53MAPTSMN1; SMN2GCGR | |
| SCHEMBL8830209 | 0.70 | NPC1 (0.44) | ALOX5TP53MAPTSMN1; SMN2 | |
| SCHEMBL9629574 | 0.70 | ALOX5 (1.00) | ALOX5TP53MAPT | |
| SCHEMBL27913336 | 0.69 | LOXL2 (0.64) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL8716614 | 0.69 | ALDH1A1 (0.51) | TP53MAPTSMN1; SMN2GPR84DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A4 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |