Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | IAPP | P10997 | 6/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10339057 | 0.87 | HPGD (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11022263 | 0.78 | LIG1 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11023732 | 0.77 | NPC1 (0.40) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL4624134 | 0.76 | SLC6A2 (0.42) | MEN1HPGDKMT2AMAPK1 | |
| SCHEMBL15981547 | 0.72 | TERT (0.46) | TERTALOX5IAPPCA12CA1 | |
| SCHEMBL8996014 | 0.72 | CTSD (0.49) | CA12CA1CA2CA9ALDH1A1 | |
| Iodide SCHEMBL8995949 | 0.72 | HSD11B1 (0.41) | KDM4EMEN1ALDH1A1KMT2ALMNA | |
| Iodide SCHEMBL2353850 | 0.71 | MDM2 (0.47) | CA12CA1CA2CA7CA9 | |
| Iodide SCHEMBL11214733 | 0.70 | LMNA (0.42) | CA12CA1CA2CA7CA9 | |
| Iodide SCHEMBL9636197 | 0.70 | KDM4E (0.54) | TERTCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241915-B1 | METHOD FOR DETERMINING CHOLINESTERASE ACTIVITY | NITTO BOSEKI CO., LTD. (JP) | 1992-07-08 | — | — | EP | claimed |
| US-4861713-A | Novel method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1989-08-29 | — | — | US | claimed |
| EP-0241915-A1 | Method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1987-10-21 | — | — | EP | claimed |
| JP-62244397-A | — | — | None | — | — | JP | disclosed |
| EP-0241915-B1 | METHOD FOR DETERMINING CHOLINESTERASE ACTIVITY | NITTO BOSEKI CO., LTD. (JP) | 1992-07-08 | — | — | EP | disclosed |
| US-4861713-A | Novel method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| JP-S62244397-A | NOVEL MEASUREMENT OF CHOLINE ESTERASE ACTIVITY | NITTO BOSEKI CO LTD | 1987-10-24 | — | — | JP | disclosed |
| EP-0241915-A1 | Method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1987-10-21 | — | — | EP | disclosed |