Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 3/20 | 0.30 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636767 | 0.79 | GID4 (0.40) | OPRK1JAK2JAK1PLATPDK1 | |
| SCHEMBL9636750 | 0.74 | OPRK1 (0.51) | OPRK1ALDH1A1 | |
| SCHEMBL10512865 | 0.73 | TSHR (0.55) | OPRK1ALDH1A1PDK1PDK2 | |
| SCHEMBL1865827 | 0.65 | MAOA (0.43) | ALDH1A1 | |
| SCHEMBL9052806 | 0.63 | VNN1 (0.35) | JAK2JAK1PLAT | |
| SCHEMBL24312822 | 0.62 | CHRNB2 (0.55) | ALDH1A1JAK2JAK1PLATPDK2 | |
| SCHEMBL9637825 | 0.61 | GID4 (0.44) | OPRK1ALDH1A1PDK1PDK2 | |
| SCHEMBL2836589 | 0.60 | OPRK1 (0.35) | OPRK1 | |
| SCHEMBL2146232 | 0.59 | CHRNB2 (0.43) | JAK2JAK1PLATPDK2 | |
| SCHEMBL2148977 | 0.59 | CHRNB2 (0.43) | JAK2JAK1PLATPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5109008-A | Analgesics, diuretics, antiischemic agents | GLAXO GROUP LIMITED (GB) | 1992-04-28 | — | — | US | disclosed |
| EP-0366327-A1 | Furo- and thieno[3,2-c]pyridines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1990-05-02 | — | — | EP | disclosed |