Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 2/20 | 0.31 |
| ▸ | CDK8 | P49336 | 2/20 | 0.31 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052285 | 0.83 | DPP4 (0.38) | DPP4DPP8DPP7HPSE | |
| SCHEMBL9044117 | 0.71 | HRH2 (0.34) | JAK2JAK1 | |
| SCHEMBL15017651 | 0.71 | HRH2 (0.34) | JAK2JAK1 | |
| SCHEMBL10512865 | 0.66 | TSHR (0.55) | — | |
| SCHEMBL929673 | 0.65 | TACR3 (0.37) | — | |
| SCHEMBL9636767 | 0.64 | GID4 (0.40) | VNN1PLATJAK2JAK1 | |
| SCHEMBL9044128 | 0.64 | VNN1 (0.40) | VNN1ACKR3 | |
| SCHEMBL9637780 | 0.63 | OPRK1 (0.41) | PLATJAK2JAK1 | |
| SCHEMBL2673131 | 0.62 | CHRNB2 (0.48) | JAK2JAK1DPP4DPP7 | |
| SCHEMBL2673133 | 0.62 | CHRNB2 (0.48) | JAK2JAK1DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743944-A1 | AZACYCLIC DERIVATIVES | SmithKline Beecham Farmaceutici S.p.A. (IT) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021843-A1 | AZACYCLIC DERIVATIVES | SMITHKLINE BEECHAM FARMACEUTICI S.P.A. (IT) | 1995-08-17 | — | — | WO | disclosed |