Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.30 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.30 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9637825 | 0.83 | GID4 (0.44) | GID4OPRK1PDK2PDK1 | |
| SCHEMBL9637780 | 0.79 | OPRK1 (0.41) | OPRK1JAK2JAK1PDK2PDK1 | |
| SCHEMBL10512865 | 0.78 | TSHR (0.55) | OPRK1PDK2PDK1CHRM2CHRM4 | |
| SCHEMBL2527846 | 0.74 | GID4 (0.55) | GID4OPRK1 | |
| SCHEMBL9636740 | 0.72 | OPRK1 (0.49) | GID4OPRK1JAK2JAK1 | |
| SCHEMBL9052806 | 0.64 | VNN1 (0.35) | JAK2JAK1PLATVNN1 | |
| SCHEMBL9636773 | 0.62 | GID4 (0.47) | GID4OPRK1 | |
| SCHEMBL1868516 | 0.61 | GID4 (0.57) | GID4 | |
| SCHEMBL3283271 | 0.61 | RAB9A (0.66) | — | |
| SCHEMBL24312822 | 0.60 | CHRNB2 (0.55) | JAK2JAK1PDK2PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5109008-A | Analgesics, diuretics, antiischemic agents | GLAXO GROUP LIMITED (GB) | 1992-04-28 | — | — | US | disclosed |
| EP-0366327-A1 | Furo- and thieno[3,2-c]pyridines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1990-05-02 | — | — | EP | disclosed |