Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TOP1 | P11387 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21999716 | 0.87 | KMT2A (0.77) | KMT2AMAPTSMN1; SMN2SLC6A3ESR1 | |
| SCHEMBL19509566 | 0.87 | KMT2A (0.77) | KMT2AMAPTSMN1; SMN2SLC6A3HSD17B10 | |
| SCHEMBL725404 | 0.87 | KMT2A (0.76) | KMT2AMAPTSMN1; SMN2SLC6A3HSD17B10 | |
| Bromide SCHEMBL29588519 | 0.85 | KMT2A (0.73) | KMT2AMAPTSMN1; SMN2SLC6A3HSD17B10 | |
| Hydrochloric Acid SCHEMBL16050041 | 0.85 | KMT2A (0.73) | KMT2AMAPTSMN1; SMN2SLC6A3HSD17B10 | |
| SCHEMBL21999712 | 0.83 | KMT2A (0.70) | KMT2AMAPTSMN1; SMN2HSD17B10ESR1 | |
| SCHEMBL19509565 | 0.83 | KMT2A (0.70) | KMT2AMAPTSMN1; SMN2SLC6A3ESR1 | |
| SCHEMBL19475609 | 0.82 | KMT2A (0.68) | KMT2AMAPTSMN1; SMN2MEN1GAA | |
| Acetic Acid SCHEMBL29588064 | 0.81 | KMT2A (0.68) | KMT2AMAPTSMN1; SMN2SLC6A3HSD17B10 | |
| SCHEMBL31517375 | 0.81 | KMT2A (0.68) | KMT2AMAPTSMN1; SMN2SLC6A3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267378-B1 | TROPOLONE DERIVATIVES AS AN ANTI-MYCOPLASMA AGENT | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-11-04 | — | — | EP | claimed |
| EP-0267378-A2 | Tropolone derivatives as an anti-mycoplasma agent | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1988-05-18 | — | — | EP | claimed |
| US-10980754-B2 | Anti-fungal compounds | SAINT LOUIS UNIVERSITY (US) | 2021-04-20 | — | — | US | disclosed |
| WO-2021041776-A1 | LIPOSOMAL TROPONOID COMPOUND FORMULATIONS | UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) | 2021-03-04 | — | — | WO | disclosed |
| US-20200147086-A1 | INHIBITORS OF NUCLEOTIDYLTRANSFERASE SUPERFAMILY ENZYMES AS ANTIBIOTICS | SAINT LOUIS UNIVERSITY (US) | 2020-05-14 | — | — | US | disclosed |
| US-10329542-B2 | HBV RNAse H purification and enzyme inhibitors | SAINT LOUIS UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2019-04-04 | — | — | US | disclosed |
| WO-2017184752-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2017-10-26 | — | — | WO | disclosed |
| US-20160296521-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2016-10-13 | — | — | US | disclosed |
| EP-0267378-B1 | TROPOLONE DERIVATIVES AS AN ANTI-MYCOPLASMA AGENT | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |
| US-4950686-A | Anti-mycoplasma agent | SHIONOGI & CO., LTD. (JP) | 1990-08-21 | — | — | US | disclosed |
| EP-0267378-A2 | Tropolone derivatives as an anti-mycoplasma agent | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1988-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | ERG28, NANS, DPM1 | KMT2A 3839/4885MAPT 3024/4885SMN1; SMN2 3958/4885 |
| US-20160296521-A1 | INHIBITORS OF HSV NUCLEOTIDYL TRANSFERASES AND USES THEREFOR | TYMP, TYMS, NAMPT | KMT2A 1441/4885MAPT 2880/4885SMN1; SMN2 4818/4885 |
| US-20200147086-A1 | INHIBITORS OF NUCLEOTIDYLTRANSFERASE SUPERFAMILY ENZYMES AS ANTIBIOTICS | DNTT, APRT, RNGTT | KMT2A 804/4885MAPT 3444/4885SMN1; SMN2 3844/4885 |
| US-10980754-B2 | Anti-fungal compounds | ERG28, NANS, DPM1 | KMT2A 3839/4885MAPT 3024/4885SMN1; SMN2 3958/4885 |
| US-10329542-B2 | HBV RNAse H purification and enzyme inhibitors | RNASEH1, RNASE1, RNASEL | KMT2A 2785/4885MAPT 4504/4885SMN1; SMN2 4207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.