Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645410 | 0.76 | MEN1 (0.43) | HTTGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9645284 | 0.74 | L3MBTL1 (0.51) | GAAL3MBTL1SMN1; SMN2CTSGCMA1 | |
| SCHEMBL9645861 | 0.71 | GRM5 (0.40) | ALDH1A1L3MBTL1LMNACYP3A4TSHR | |
| SCHEMBL9645288 | 0.71 | GAA (0.44) | GAAALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL9645470 | 0.70 | POLB (0.42) | HTTGAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL13777921 | 0.70 | KMT2A (0.47) | GAAALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL3392318 | 0.70 | TSHR (0.59) | HTTALDH1A1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL9453365 | 0.68 | MEN1 (0.38) | ALDH1A1L3MBTL1CTSGCMA1CYP1A2 | |
| SCHEMBL7979583 | 0.68 | TSHR (0.53) | HTTALDH1A1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL9645251 | 0.67 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1SMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |