SCHEMBL9650705

SCHEMBL9650705

CC(=O)N1CCNC(CO)C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
REN P00797 3/20 0.39
CHRNB2 P17787 4/20 0.38
CHRNA3 P32297 4/20 0.38
CHRNA4 P43681 4/20 0.38
CHRNB3 Q05901 2/20 0.38
CHRNA6 Q15825 2/20 0.38
CA1 P00915 4/20 0.38
CA2 P00918 4/20 0.38
CA4 P22748 4/20 0.38
CA9 Q16790 4/20 0.38
CHRNB4 P30926 2/20 0.37
BIRC2 Q13490 1/20 0.36
CHRNA7 P36544 1/20 0.35
SCN9A Q15858 4/20 0.34
ITGB2 P05107 1/20 0.34
ICAM1 P05362 1/20 0.34
ITGAL P20701 1/20 0.34
CYP1A2 P05177 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PARP1 P09874 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9651732 1.00 REN (0.39) RENCHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL12642488 0.85 PARP1 (0.43) RENCHRNB2CHRNA3CHRNA4CHRNB3
Hydrochloric Acid SCHEMBL18150515 0.84 PARP1 (0.42) RENCHRNB2CHRNA3CHRNA4CHRNB3
Hydrochloric Acid SCHEMBL18150513 0.84 PARP1 (0.42) RENCHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL2418102 0.83 REN (0.42) RENCHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL15005734 0.83 REN (0.42) RENCHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL2011996 0.83 REN (0.42) RENCHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL16508868 0.82 CHRNB2 (0.44) RENCHRNB2CHRNA3CHRNA4CHRNB3
SCHEMBL28526802 0.82 CHRNB2 (0.40) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL3776345 0.81 REN (0.41) RENCHRNB2CHRNA3CHRNA4CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12433949-B2 Sustained release delivery systems comprising traceless linkers NOVARTIS AG (CH) 2025-10-07 US disclosed
CN-119185569-A Sustained release delivery system comprising a traceless linker 诺华股份有限公司 2024-12-27 CN disclosed
US-20230201353-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS NOVARTIS AG (CH) 2023-06-29 US disclosed
US-20230201353-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS NOVARTIS AG (CH) 2023-06-29 US disclosed
US-20230201353-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS NOVARTIS AG (CH) 2023-06-29 US disclosed
US-20200376129-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2020-12-03 US disclosed
US-20200376129-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2020-12-03 US disclosed
US-10751417-B2 Sustained release delivery systems comprising traceless linkers NOVARTIS AG (CH) 2020-08-25 US disclosed
US-10751417-B2 Sustained release delivery systems comprising traceless linkers NOVARTIS AG (CH) 2020-08-25 US disclosed
EP-3612233-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS Novartis AG (CH) 2020-02-26 EP disclosed
WO-2018193408-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS NOVARTIS AG (CH) 2018-10-25 WO disclosed
EP-3092229-B1 PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS BRISTOL MYERS SQUIBB CO (US) 2018-03-28 EP disclosed
US-20160326108-A1 PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS BRISTOL MYERS SQUIBB CO (US) 2016-11-10 US disclosed
US-9458171-B2 Pyrrolidinyl sulfone RORγ modulators BRISTOL-MYERS SQUIBB COMPANY (US) 2016-10-04 US disclosed
WO-2015103509-A1 PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-07-09 WO disclosed
US-20150191483-A1 PYRROLIDINYL SULFONE RORGAMMA MODULATORS BRISTOL-MYERS SQUIBB COMPANY 2015-07-09 US disclosed
US-5116842-A Analgesics GLAXO GROUP LIMITED (GB) 1992-05-26 US disclosed
EP-0398720-A2 Piperazine derivatives GLAXO GROUP LIMITED (GB) 1990-11-22 EP disclosed
US-4943578-A ANALGESICS; CEREBRAL ANTIISCHEMIC AGENTS GLAXO GROUP LIMITED (GB) 1990-07-24 US disclosed
EP-0343900-A2 Piperazine compounds GLAXO GROUP LIMITED (GB) 1989-11-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230201353-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS ABCB11, ABCB1, GHRHR REN 2904/4885CHRNB2 2595/4885CHRNA3 3155/4885
US-20200376129-A1 SUSTAINED RELEASE DELIVERY SYSTEMS COMPRISING TRACELESS LINKERS ABCB11, ABCB1, GHRHR REN 2904/4885CHRNB2 2595/4885CHRNA3 3155/4885
US-10751417-B2 Sustained release delivery systems comprising traceless linkers ABCB11, ABCB1, GHRHR REN 2904/4885CHRNB2 2595/4885CHRNA3 3155/4885
US-12433949-B2 Sustained release delivery systems comprising traceless linkers ABCB11, ABCB1, GHRHR REN 2904/4885CHRNB2 2595/4885CHRNA3 3155/4885
US-20160326108-A1 PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS RORC, RORB, RORA REN 670/4885CHRNB2 2052/4885CHRNA3 1470/4885
US-20150191483-A1 PYRROLIDINYL SULFONE RORGAMMA MODULATORS RORC, RORB, RORA REN 1100/4885CHRNB2 1404/4885CHRNA3 1165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.