Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235680 | 0.98 | TP53 (0.48) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| Bromide SCHEMBL9320165 | 0.95 | TP53 (0.46) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| SCHEMBL2603135 | 0.85 | TP53 (0.48) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| Bromide SCHEMBL1046180 | 0.82 | TP53 (0.46) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| Hydrochloric Acid SCHEMBL394410 | 0.82 | TP53 (0.42) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| SCHEMBL395841 | 0.79 | TP53 (0.44) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| Hydrochloric Acid SCHEMBL967040 | 0.78 | TP53 (0.48) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| Hydrochloric Acid SCHEMBL968647 | 0.77 | ALDH1A1 (0.50) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| SCHEMBL390922 | 0.76 | TP53 (0.40) | TP53ALDH1A1KDM4ETDP1TAAR1 | |
| Perchlorate SCHEMBL5034610 | 0.76 | TSHR (0.40) | TP53ALDH1A1KDM4ETDP1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110015442-A1 | SULFONE COMPOUND AND METHOD FOR PRODUCING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-01-20 | — | — | US | disclosed |
| US-20110015441-A1 | SULFONE COMPOUND AND PROCESS FOR PRODUCING CAROTENOID USING THE SAME COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-01-20 | — | — | US | disclosed |
| EP-2261204-A1 | SULFONE COMPOUND AND METHOD FOR PRODUCING THE SAME | Sumitomo Chemical Company, Limited (JP) | 2010-12-15 | — | — | EP | disclosed |
| EP-2253613-A1 | SULFONE COMPOUND AND CAROTENOID MANUFACTURING METHOD USING SAID COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2010-11-24 | — | — | EP | disclosed |
| EP-1231197-A1 | Process for producing allyl halide compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-08-14 | — | — | EP | disclosed |
| US-20020107422-A1 | Process for producing allyl halide compound | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2002-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015442-A1 | SULFONE COMPOUND AND METHOD FOR PRODUCING THE SAME | MSRB3, HCN4, SULT1E1 | SLC6A2 2947/4885SLC6A3 1450/4885TP53 2440/4885 |
| US-20110015441-A1 | SULFONE COMPOUND AND PROCESS FOR PRODUCING CAROTENOID USING THE SAME COMPOUND | SCLY, ENY2, ZYX | SLC6A2 3932/4885SLC6A3 2232/4885TP53 4736/4885 |
| US-20020107422-A1 | Process for producing allyl halide compound | ENY2, ZYX, RPS4Y1 | SLC6A2 4630/4885SLC6A3 4594/4885TP53 4712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.