Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682445 | 0.80 | MAPT (0.54) | MAPTALDH1A1POLBIDO1TDO2 | |
| SCHEMBL9682449 | 0.80 | TRAP1 (0.44) | MAPTALDH1A1MEN1KMT2AAKR1B1 | |
| SCHEMBL9681363 | 0.75 | MAPT (0.55) | MAPTALDH1A1POLBPRKCQAHR | |
| SCHEMBL31048492 | 0.75 | PRKCQ (0.43) | MAPTALDH1A1POLBPRKCQMEN1 | |
| SCHEMBL6715157 | 0.73 | P2RX7 (0.38) | MAPTALDH1A1PRKCQMEN1KMT2A | |
| SCHEMBL9682000 | 0.72 | MAPT (0.51) | MAPTALDH1A1POLBPRKCQALDH3A1 | |
| SCHEMBL10487794 | 0.72 | HPGD (0.62) | ALDH1A1POLBKMT2AGAAAKR1B1 | |
| SCHEMBL9683485 | 0.70 | MAPT (0.60) | MAPTALDH1A1POLBIDO1TDO2 | |
| SCHEMBL9683229 | 0.70 | MAPT (0.47) | MAPTALDH1A1PRKCQAHRMEN1 | |
| SCHEMBL3850551 | 0.69 | PRKCQ (0.50) | MAPTPRKCQMAPK1EGFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |