Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 5/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680964 | 0.80 | MAPT (0.42) | AKR1B1MEN1KMT2AMAPTEGFR | |
| SCHEMBL9683479 | 0.77 | AKR1B1 (0.43) | TRAP1HSP90AA1HSP90AB1BACE1BACE2 | |
| SCHEMBL9681910 | 0.72 | APP (0.47) | MAPTEGFRALDH1A1 | |
| SCHEMBL27456222 | 0.72 | FADS1 (0.49) | AKR1B1 | |
| SCHEMBL16489590 | 0.71 | EGFR (0.51) | BACE1HPGDHTTEGFRABL1 | |
| SCHEMBL9681422 | 0.69 | HDAC1 (0.40) | TRAP1HSP90B1AKR1B1ADRA2BMAPT | |
| SCHEMBL23292038 | 0.68 | ALDH1A1 (0.52) | ADRA2BMEN1KMT2AMAPTHPGD | |
| SCHEMBL7746178 | 0.68 | AKR1B1 (0.66) | AKR1B1KMT2AMAPTHPGDABL1 | |
| SCHEMBL11158402 | 0.67 | KDM1A (0.48) | TRAP1HSP90AA1HSP90AB1HSP90B1AKR1B1 | |
| SCHEMBL9683520 | 0.66 | TRPM5 (0.43) | AKR1B1ADRA2BBCDIN3DMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |