Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9779266 | 0.81 | NR1I2 (0.60) | TSHRLMNASIGMAR1 | |
| SCHEMBL4293307 | 0.79 | G6PC1 (0.47) | ALDH1A1TSHRAOC3KDM4E | |
| SCHEMBL7324033 | 0.79 | ALDH1A1 (0.54) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Dibemethine SCHEMBL10542007 | 0.78 | ALDH1A1 (0.70) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Dibemethine SCHEMBL276863 | 0.78 | ALDH1A1 (0.70) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL185582 | 0.78 | PYCR1 (0.67) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL265489 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL11470018 | 0.77 | SLC6A2 (0.46) | TSHRLMNACYP3A4SIGMAR1 | |
| SCHEMBL1382738 | 0.76 | KDM4E (0.42) | ALDH1A1TSHRKDM4E | |
| Hydrochloric Acid SCHEMBL251246 | 0.76 | PYCR1 (0.65) | ALDH1A1TSHRCARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159040-B1 | PYRIDINE DERIVATIVES AND PRODUCTION THEREOF | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1992-12-09 | — | — | EP | disclosed |
| US-5036059-A | Hypotensive agents, vasodilators | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1991-07-30 | — | — | US | disclosed |
| EP-0121117-B1 | DERIVATIVES OF DIHYDROPYRIDINE AND PRODUCTION THEREOF | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0159040-A2 | Pyridine derivatives and production thereof | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4535073-A | VASODILATION | NIPPON SHINYAKU CO LIMITED (JP) | 1985-08-13 | — | — | US | disclosed |
| EP-0121117-A1 | Derivatives of dihydropyridine and production thereof | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1984-10-10 | — | — | EP | disclosed |