Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | HTR1B | P28222 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PFKFB2 | O60825 | 3/20 | 0.35 |
| ▸ | PFKFB1 | P16118 | 3/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765092 | 0.87 | PLA2G4A (0.45) | HTR6ICMTIMPDH2MEN1KMT2A | |
| SCHEMBL9687324 | 0.81 | HTR1A (0.57) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9687692 | 0.80 | HTR1A (0.56) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL10465857 | 0.73 | CACNB4 (0.46) | HTR6ICMT | |
| SCHEMBL9765114 | 0.72 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL10465308 | 0.71 | CACNB4 (0.42) | HTR6ICMTMEN1KMT2ACYP19A1 | |
| SCHEMBL9765119 | 0.71 | CA2 (0.39) | HTR1DHTR2AMETHTR6IMPDH2 | |
| SCHEMBL13651695 | 0.70 | HTR1A (0.56) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL10465880 | 0.70 | PLA2G2A (0.47) | HTR6 | |
| SCHEMBL9687900 | 0.70 | HTR1A (0.55) | HTR1DHTR1BHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992014708-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500086-A1 | Indole derivatives, their use as medicines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1992-08-26 | — | — | EP | disclosed |