Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688926 | 0.81 | HTR1A (0.46) | AOC3HTR1A | |
| SCHEMBL2939712 | 0.78 | GAA (0.40) | AOC3 | |
| SCHEMBL4360488 | 0.77 | AOC3 (0.55) | AOC3HTR2AHTR1ANOS1NOS3 | |
| SCHEMBL9688847 | 0.76 | TAAR1 (0.41) | HTR2AHTR1AHTR6 | |
| SCHEMBL31618142 | 0.74 | CYP2C9 (0.54) | AOC3HTR2AHTR1AHTR6 | |
| SCHEMBL1710455 | 0.73 | ALDH1A1 (0.50) | ACHE | |
| SCHEMBL1014275 | 0.73 | ALDH1A1 (0.50) | ACHE | |
| SCHEMBL2937482 | 0.72 | AOC3 (0.73) | AOC3HTR2AHTR1AHTR6 | |
| SCHEMBL9689684 | 0.71 | NOS1 (0.43) | AOC3HTR2AHTR1ANOS1HTR6 | |
| SCHEMBL9689679 | 0.71 | HTR6 (0.45) | AOC3HTR2AHTR1ANOS1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |