Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688171 | 0.89 | PADI1 (0.41) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9689107 | 0.82 | TDP1 (0.41) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9688628 | 0.81 | ALDH1A1 (0.52) | TSHRALDH1A1L3MBTL1TDP1NPC1 | |
| SCHEMBL9688728 | 0.80 | MAPK1 (0.38) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9689342 | 0.78 | ALDH1A1 (0.43) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9688014 | 0.77 | NPC1 (0.47) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9689730 | 0.77 | ALDH1A1 (0.45) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9687989 | 0.76 | ELANE (0.38) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9689977 | 0.76 | TDP1 (0.36) | TSHRALDH1A1L3MBTL1TDP1MAPK1 | |
| SCHEMBL9689991 | 0.76 | ALDH1A1 (0.44) | TSHRALDH1A1TDP1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |