Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689617 | 0.84 | DRD2 (0.55) | KCNH2PTGS2NR1I2ADRB2ADORA3 | |
| SCHEMBL9690259 | 0.74 | KCNH2 (0.41) | KCNH2PTGS2NR1I2ADRB2ADORA3 | |
| SCHEMBL9689297 | 0.72 | CBX7 (0.51) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9689667 | 0.72 | KDM4E (0.45) | KCNH2PTGS2NR1I2ADRB2ADORA3 | |
| SCHEMBL9689736 | 0.71 | BRPF1 (0.40) | KCNH2PTGS2NR1I2ADRB2ADORA3 | |
| SCHEMBL9689266 | 0.71 | PRMT5 (0.42) | KCNH2PTGS2NR1I2ADRB2ADORA3 | |
| SCHEMBL9689654 | 0.70 | HTR6 (0.41) | ADRB2TDP1ADRB1MAPTALDH1A1 | |
| SCHEMBL9689271 | 0.69 | RAB9A (0.49) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9689762 | 0.68 | NPC1 (0.39) | KCNH2PTGS2ADRB2TDP1ADRB1 | |
| SCHEMBL9689716 | 0.68 | NR3C2 (0.56) | PTGS2GRIN2BALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |