Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689750 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ARECQLPOLB | |
| SCHEMBL9688805 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ARECQLPOLB | |
| SCHEMBL9688171 | 0.77 | PADI1 (0.41) | ALDH1A1MEN1KMT2ARECQLPOLB | |
| SCHEMBL9689319 | 0.76 | TSHR (0.43) | ALDH1A1KMT2ATDP1KDM4EMAPT | |
| SCHEMBL9689070 | 0.75 | SMN1; SMN2 (0.48) | ALDH1A1MEN1KMT2ARECQLPOLB | |
| SCHEMBL9688818 | 0.75 | RECQL (0.66) | ALDH1A1MEN1KMT2ARECQLPOLB | |
| SCHEMBL9689783 | 0.75 | TSHR (0.36) | ALDH1A1MEN1KMT2ARECQLPOLB | |
| SCHEMBL9689827 | 0.73 | CASP3 (0.35) | ALDH1A1MEN1KMT2ARECQLTHRB | |
| SCHEMBL9689183 | 0.72 | GSK3B (0.47) | ALDH1A1MEN1KMT2ARECQLPOLB | |
| SCHEMBL30733945 | 0.71 | KMT2A (0.47) | ALDH1A1MEN1KMT2ARECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |