Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.42 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.42 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.42 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | CACNA1E | Q15878 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689722 | 0.90 | FABP4 (0.47) | FABP4HTR6KDM4EALDH1A1GABRP | |
| SCHEMBL9688920 | 0.87 | FABP4 (0.52) | FABP4HTR6BCHEKDM4EALDH1A1 | |
| SCHEMBL9689810 | 0.84 | FABP4 (0.43) | FABP4HTR6ACHECACNB4CACNA1A | |
| SCHEMBL9690457 | 0.79 | GABRP (0.59) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL9690486 | 0.77 | FABP4 (0.47) | FABP4HTR6KDM4EALDH1A1GLA | |
| SCHEMBL9382989 | 0.77 | HTR6 (0.44) | FABP4HTR6ACHEBCHEKDM4E | |
| SCHEMBL9383301 | 0.74 | CYP11B2 (0.46) | FABP4HTR6ACHEKDM4EALDH1A1 | |
| SCHEMBL9382045 | 0.72 | ALDH1A1 (0.46) | FABP4HTR6KDM4EALDH1A1GAA | |
| SCHEMBL17406863 | 0.70 | FABP4 (0.47) | FABP4HTR6KDM4EALDH1A1 | |
| SCHEMBL17406866 | 0.69 | ALDH1A1 (0.46) | FABP4HTR6KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249301-B1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1992-05-27 | — | — | EP | claimed |
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | claimed |
| EP-0249301-B1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1992-05-27 | — | — | EP | disclosed |
| US-4952584-A | TREATMENT OF PROPHYLAXIS OF ANXIETY OR DEPRESSION | BEECHAM GROUP P.L.C. (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0249301-A1 | Pyrido[2,3-b]indoles | BEECHAM GROUP PLC (GB) | 1987-12-16 | — | — | EP | disclosed |