Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703793 | 0.86 | DRD2 (0.56) | DRD2DRD3DRD4 | |
| SCHEMBL9703843 | 0.81 | DRD2 (0.52) | DRD2DRD3DRD4SIGMAR1HTR1A | |
| SCHEMBL9773113 | 0.79 | DRD2 (0.57) | DRD2DRD3DRD4SIGMAR1HTR1A | |
| SCHEMBL9703331 | 0.78 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL9703330 | 0.77 | DRD2 (0.81) | DRD2DRD3DRD4 | |
| SCHEMBL9204778 | 0.74 | DRD2 (0.54) | DRD2DRD3DRD4SIGMAR1HTR1A | |
| SCHEMBL7700873 | 0.70 | ADRA1D (0.65) | DRD2DRD3DRD4SLC6A4 | |
| SCHEMBL9703158 | 0.69 | DRD2 (0.81) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9703250 | 0.68 | DRD2 (0.79) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9703912 | 0.68 | DRD2 (0.79) | DRD2DRD3DRD4SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | claimed |
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |