Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703793 | 0.86 | DRD2 (0.56) | DRD2DRD4DRD3 | |
| SCHEMBL9705545 | 0.81 | DRD2 (0.64) | DRD2DRD4DRD3HTR1ASIGMAR1 | |
| SCHEMBL10574063 | 0.76 | SIGMAR1 (0.60) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL10578390 | 0.74 | HTR1A (0.51) | DRD2HTR1AHTR2ASIGMAR1 | |
| SCHEMBL9367259 | 0.72 | SIGMAR1 (0.49) | DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL7700873 | 0.70 | ADRA1D (0.65) | DRD2DRD4DRD3ADRA1D | |
| SCHEMBL9703330 | 0.69 | DRD2 (0.81) | DRD2DRD4DRD3ADRA1D | |
| SCHEMBL9703331 | 0.68 | DRD2 (1.00) | DRD2DRD4DRD3ADRA1D | |
| SCHEMBL10744763 | 0.68 | DRD1 (0.43) | DRD2DRD4DRD3HTR1AHTR2A | |
| SCHEMBL10577937 | 0.67 | SIGMAR1 (0.59) | DRD2HTR1AHTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | claimed |
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |