SCHEMBL9706623

SCHEMBL9706623

Cn1c2c(c(=O)n(-c3cc(C(=O)O)c(Br)cc3F)c1=O)CCC2

nearest known ligand 0.32

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.32
JAK2 O60674 1/20 0.31
BTK Q06187 1/20 0.31
RXFP1 Q9HBX9 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CMA1 P23946 1/20 0.31
GAA P10253 1/20 0.31
RXRA P19793 1/20 0.30
RXRB P28702 1/20 0.30
RXRG P48443 1/20 0.30
LCK P06239 1/20 0.30
FYN P06241 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10873317 0.90 RXRA (0.34) TTRRXFP1CMA1GAARXRA
SCHEMBL9706554 0.87 HPGD (0.34) TTRRXFP1SMN1; SMN2CMA1GAA
SCHEMBL9706678 0.87 CMA1 (0.34) RXFP1SMN1; SMN2CMA1GAALCK
SCHEMBL10645585 0.86 HPGD (0.34) TTRRXFP1SMN1; SMN2CMA1GAA
SCHEMBL9706594 0.86 OPRK1 (0.30)
SCHEMBL9706687 0.84 HPGD (0.34) RXFP1SMN1; SMN2CMA1
SCHEMBL9423141 0.80 TSHR (0.36) RXFP1SMN1; SMN2
SCHEMBL10645580 0.78 HPGD (0.31) RXFP1SMN1; SMN2
SCHEMBL9706680 0.78 LMNA (0.37) RXFP1CMA1GAA
SCHEMBL10645208 0.78 KDM4E (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0195346-B1 3-ARYL URACILES AND THEIR USE AS HERBICIDES CIBA-GEIGY AG (CH) 1992-06-24 EP claimed