Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 8/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9708813 | 0.93 | RAB9A (0.44) | PDE1APDE1BPDE1CTSHRSMN1; SMN2 | |
| SCHEMBL9708505 | 0.91 | ADORA3 (0.42) | — | |
| SCHEMBL9708391 | 0.91 | PDE1A (0.44) | PDE1APDE1BPDE1CHPGDPDE5A | |
| SCHEMBL9707553 | 0.90 | PDE1A (0.43) | PDE1APDE1BPDE1CPDE5ATSHR | |
| SCHEMBL9707423 | 0.90 | ADORA3 (0.42) | — | |
| SCHEMBL9708256 | 0.90 | HPGD (0.44) | HPGD | |
| SCHEMBL9707691 | 0.90 | ADORA3 (0.42) | PDE1APDE1BPDE1C | |
| SCHEMBL9708711 | 0.89 | ALOX15 (0.46) | TSHRSMN1; SMN2LMNANPSR1ALDH1A1 | |
| SCHEMBL9708087 | 0.89 | ADORA1 (0.38) | PDE1APDE1BPDE1C | |
| SCHEMBL9708265 | 0.89 | DCTPP1 (0.41) | PDE5AMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007852-A1 | BIPHENYLALKYL XANTHINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |