SCHEMBL9711474

SCHEMBL9711474

O=C1CC(c2ccccc2)NC(=O)C1C(=O)c1cccc(OC(F)(F)F)c1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.42
MGLL Q99685 3/20 0.41
KAT6A Q92794 3/20 0.40
TAS1R3 Q7RTX0 1/20 0.39
TAS1R1 Q7RTX1 1/20 0.39
TAS1R2 Q8TE23 1/20 0.39
GPR139 Q6DWJ6 1/20 0.39
NOTUM Q6P988 1/20 0.39
NAMPT P43490 1/20 0.38
MAPK14 Q16539 1/20 0.38
CHRM3 P20309 1/20 0.37
EPHX2 P34913 1/20 0.37
CETP P11597 1/20 0.36
SLC5A1 P13866 2/20 0.36
PTGDR2 Q9Y5Y4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9711533 0.86 NPC1 (0.43)
SCHEMBL9711648 0.84 CES2 (0.43) HSD11B1MGLL
SCHEMBL9711454 0.81 MAPT (0.44)
SCHEMBL9711523 0.80 SLC6A3 (0.40) MGLL
SCHEMBL9711470 0.80 EPHX1 (0.43)
SCHEMBL9711528 0.80 F2RL1 (0.42)
SCHEMBL9711658 0.79 HSD11B1 (0.40) HSD11B1MGLL
SCHEMBL9711601 0.78 HSD11B1 (0.44) HSD11B1MGLLKAT6ATAS1R3TAS1R1
SCHEMBL9711548 0.78 HDAC11 (0.43) HSD11B1MGLL
SCHEMBL9711582 0.76 LMNA (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5114461-A Herbicides MAY & BAKER LIMITED (GB) 1992-05-19 US disclosed
EP-0278742-A2 Cyclic diones MAY & BAKER LIMITED (GB) 1988-08-17 EP disclosed