SCHEMBL9711523

SCHEMBL9711523

O=C1CC(c2ccccc2)NC(=O)C1C(=O)c1cccc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 2/20 0.40
NPSR1 Q6W5P4 2/20 0.39
GSK3B P49841 1/20 0.39
LDHA P00338 3/20 0.39
KDM2B Q8NHM5 2/20 0.39
LDHB P07195 1/20 0.38
GRM5 P41594 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
PARP1 P09874 1/20 0.37
MGLL Q99685 1/20 0.37
ALDH1A1 P00352 1/20 0.37
DRD2 P14416 1/20 0.37
DRD4 P21917 1/20 0.37
DRD3 P35462 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9711454 0.87 MAPT (0.44) LDHALDHBMEN1KMT2AALDH1A1
SCHEMBL9711470 0.85 EPHX1 (0.43) NPSR1MEN1KMT2APARP1ALDH1A1
SCHEMBL9711528 0.85 F2RL1 (0.42) NPSR1MEN1KMT2APARP1ALDH1A1
SCHEMBL9711698 0.85 KMO (0.43) SLC6A3LDHALDHB
SCHEMBL9711533 0.82 NPC1 (0.43) KDM2BKMT2APARP1ALDH1A1
SCHEMBL9711648 0.82 CES2 (0.43) MEN1KMT2AMGLL
SCHEMBL9711476 0.82 LDHA (0.44) SLC6A3LDHALDHBMEN1KMT2A
SCHEMBL9711582 0.81 LMNA (0.49) NPSR1MEN1KMT2AALDH1A1
SCHEMBL9711474 0.80 HSD11B1 (0.42) MGLL
SCHEMBL9711543 0.80 LDHA (0.44) SLC6A3LDHALDHBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5114461-A Herbicides MAY & BAKER LIMITED (GB) 1992-05-19 US disclosed
EP-0278742-A2 Cyclic diones MAY & BAKER LIMITED (GB) 1988-08-17 EP disclosed