Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714594 | 0.89 | GPBAR1 (0.55) | GPBAR1GRM2ROCK2MAPK8PLK4 | |
| SCHEMBL9714409 | 0.78 | AURKA (0.40) | GPBAR1GRM2ALKBH1PTGDR2AURKA | |
| SCHEMBL9714161 | 0.76 | CA5A (0.48) | GPBAR1GRM2ROCK2MAPK8TGFBR1 | |
| SCHEMBL31333082 | 0.75 | ROCK2 (0.39) | GRM2ROCK2MAPK8ALKBH1PTGDR2 | |
| SCHEMBL30092573 | 0.70 | RIPK1 (0.43) | MAPK8RIPK1DPP4TUBB4ATUBB | |
| SCHEMBL9714457 | 0.70 | GRM2 (0.43) | GRM2MAPK8ALKBH1RIPK1DPP4 | |
| SCHEMBL2145230 | 0.70 | KMT2A (0.53) | GPBAR1ROCK2KDM4EALDH1A1 | |
| SCHEMBL24791689 | 0.68 | HTR7 (0.43) | ROCK2TGFBR1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL16628334 | 0.68 | NPC1 (0.44) | GRM2MAPK8RPS6KB1KDM4E | |
| SCHEMBL3487419 | 0.68 | ADRA1D (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | claimed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | claimed |
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |