Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714161 | 0.85 | CA5A (0.48) | GPBAR1CA5AGRM2 | |
| SCHEMBL10569749 | 0.81 | CYP11B2 (0.46) | LMNA | |
| SCHEMBL9714594 | 0.78 | GPBAR1 (0.55) | AURKARPS6KB1GPBAR1GRM2 | |
| SCHEMBL9714101 | 0.78 | GPBAR1 (0.45) | AURKARPS6KB1GPBAR1ALKBH1GRM2 | |
| SCHEMBL10771365 | 0.76 | ALKBH1 (0.40) | LMNAALKBH1P2RX7METPTGDR2 | |
| SCHEMBL2145230 | 0.72 | KMT2A (0.53) | LMNAGPBAR1 | |
| SCHEMBL30092550 | 0.70 | AURKA (0.42) | AURKAPDPK1RPS6KB1CA5AP2RX7 | |
| SCHEMBL9714289 | 0.70 | CA5A (0.45) | AURKAPDPK1RPS6KB1ALKBH1CA5A | |
| SCHEMBL21043084 | 0.69 | NPC1 (0.47) | AURKAPDPK1RPS6KB1 | |
| SCHEMBL24791689 | 0.68 | HTR7 (0.43) | LMNAHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |