Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980569 | 0.86 | ADORA1 (0.61) | ALDH1A1PRKCZMEN1KMT2AHPGD | |
| SCHEMBL3980970 | 0.85 | ALDH1A1 (0.65) | ALDH1A1PRKCZMEN1KMT2AHPGD | |
| SCHEMBL3974068 | 0.85 | CNR2 (0.51) | ALDH1A1PRKCZMEN1KMT2AHPGD | |
| SCHEMBL28599809 | 0.83 | PRKCZ (0.48) | ALDH1A1PRKCZMEN1KMT2AHPGD | |
| SCHEMBL3972011 | 0.82 | PRKCZ (0.57) | ALDH1A1PRKCZMEN1KMT2AHPGD | |
| SCHEMBL136381 | 0.82 | ALDH1A1 (0.61) | ALDH1A1PRKCZMEN1KMT2AHPGD | |
| SCHEMBL3972275 | 0.80 | RORB (0.49) | ALDH1A1PRKCZMEN1KMT2ALMNA | |
| SCHEMBL3976339 | 0.79 | PRKCZ (0.58) | ALDH1A1PRKCZMEN1KMT2AHPGD | |
| SCHEMBL3975701 | 0.78 | ADORA1 (0.50) | PRKCZMEN1KMT2ALMNAADORA1 | |
| SCHEMBL3976107 | 0.76 | PRKCZ (0.58) | ALDH1A1PRKCZMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1028408-C | Process for preparation of compositions containing novel 1, 4-diaza * derivatives having antiulcer activity | DUPHAR INT RES (NL) | 1995-05-17 | — | — | CN | disclosed |
| US-5140024-A | Thienofuro- or thienodiazepines and pyridofuro- or thienodizsepines; antisecretory and -inflammatory agents; gastrointestinal disorders | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1992-08-18 | — | — | US | disclosed |
| US-4985423-A | New 1,4-diazepine derivatives having anit-ulcer activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-01-15 | — | — | US | disclosed |
| CN-1040027-A | Have the new 1 of antiulcer activity, 4-diaza derivative | DUPHAR INT RES (NL) | 1990-02-28 | — | — | CN | disclosed |
| EP-0350131-A2 | New 1,4-diazepine derivatives having anti-ulcer activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-01-10 | — | — | EP | disclosed |