Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 3/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726814 | 0.82 | PDE9A (0.57) | PDE9APDE1APDE1BPDE1CGRM2 | |
| SCHEMBL9726545 | 0.80 | PDE5A (0.41) | SMN1; SMN2MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL10366265 | 0.74 | BRD4 (0.52) | PDE1APDE1BPDE1CGRM2RAB9A | |
| SCHEMBL9777009 | 0.73 | TDP1 (0.49) | MAPK14RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL9726529 | 0.73 | PDE9A (0.45) | PDE9APDE1APDE1BPDE1CMAPK14 | |
| SCHEMBL10680239 | 0.73 | MTNR1B (0.45) | SMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL10602679 | 0.72 | NR3C1 (0.44) | MAPK14RAB9ASMN1; SMN2MEN1MAPT | |
| SCHEMBL9726516 | 0.71 | PDE9A (0.56) | PDE9APDE1APDE1BPDE1CGRM2 | |
| SCHEMBL1311870 | 0.71 | NPBWR1 (0.63) | PDE1APDE1BPDE1CRAB9ASMN1; SMN2 | |
| SCHEMBL9726564 | 0.71 | PDE9A (0.58) | PDE9APDE1APDE1BPDE1CGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | claimed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | claimed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | claimed |