Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9852252 | 0.92 | DRD4 (0.59) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| Iodide SCHEMBL9727152 | 0.81 | DRD4 (0.47) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9727091 | 0.80 | DRD4 (0.70) | RAB9AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9852101 | 0.80 | KMT2A (0.54) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9727072 | 0.76 | UTS2R (0.68) | RAB9APOLBUTS2RDRD4ACHE | |
| SCHEMBL9852062 | 0.73 | DRD4 (0.71) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6084166 | 0.73 | RAB9A (0.78) | RAB9ATP53MAPTNPC1SMN1; SMN2 | |
| SCHEMBL6084174 | 0.73 | RAB9A (0.78) | RAB9ATP53MAPTNPC1SMN1; SMN2 | |
| SCHEMBL9852060 | 0.73 | ACHE (0.60) | RAB9ATP53TSHRPOLBKDM4E | |
| SCHEMBL29233574 | 0.71 | RAB9A (0.58) | RAB9ATP53NPC1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |