Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9727148 | 0.92 | RAB9A (0.56) | DRD4ACHEUTS2RKDM4EALDH1A1 | |
| SCHEMBL9727091 | 0.91 | DRD4 (0.70) | DRD4ACHEUTS2RMCHR1KCNH2 | |
| Iodide SCHEMBL9852255 | 0.84 | DRD4 (0.60) | DRD4ACHEMCHR1KCNH2SIGMAR1 | |
| SCHEMBL9852062 | 0.82 | DRD4 (0.71) | DRD4ACHEUTS2RMCHR1KCNH2 | |
| SCHEMBL9852064 | 0.81 | MCHR1 (0.66) | DRD4ACHEUTS2RMCHR1KCNH2 | |
| SCHEMBL9727140 | 0.80 | UTS2R (0.73) | DRD4ACHEUTS2RMCHR1KCNH2 | |
| SCHEMBL9727072 | 0.80 | UTS2R (0.68) | DRD4ACHEUTS2RMCHR1DRD2 | |
| SCHEMBL9727136 | 0.80 | DRD4 (0.67) | DRD4ACHEKDM4EALDH1A1HPGD | |
| SCHEMBL9727131 | 0.80 | MAOB (0.74) | DRD4ACHEUTS2RMCHR1KCNH2 | |
| SCHEMBL9727231 | 0.80 | MCHR1 (0.64) | DRD4ACHEMCHR1KCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |