Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732661 | 0.87 | RAB9A (0.47) | ALDH1A1KDM4ERAB9ASMN1; SMN2HTT | |
| SCHEMBL9732429 | 0.84 | CYSLTR1 (0.42) | ALDH1A1KDM4EGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL9739211 | 0.72 | DRD2 (0.56) | ALDH1A1KDM4EGAAGPBAR1CYSLTR1 | |
| SCHEMBL9732564 | 0.71 | MAPT (0.39) | ALDH1A1KDM4EGAAGPBAR1CYSLTR1 | |
| SCHEMBL2567854 | 0.71 | LMNA (0.69) | ALDH1A1KDM4EGAAGPBAR1CYSLTR1 | |
| SCHEMBL9447021 | 0.69 | ALDH1A1 (0.53) | ALDH1A1KDM4EGAARAB9ASMN1; SMN2 | |
| SCHEMBL9753047 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAARAB9ASMN1; SMN2 | |
| SCHEMBL9737655 | 0.68 | KCNH2 (0.59) | ALDH1A1KDM4EGAAGPBAR1CYSLTR1 | |
| SCHEMBL9733327 | 0.66 | ALDH1A1 (0.55) | ALDH1A1KDM4EGAASMN1; SMN2MAPK1 | |
| SCHEMBL9737324 | 0.66 | ALDH1A1 (0.55) | ALDH1A1KDM4EGAASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104892-A | N-heteroalkyl substitutes 1-aryloxy-2-propanolamine | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-14 | — | — | US | disclosed |
| WO-1991009023-A1 | N-HETEROARALKYL-SUBSTITUTED 1-ARYLOXY-2-PROPANOLAMINE AND PROPYLAMINE DERIVATIVES POSSESSING CLASS III ANTIARRHYTHMIC ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-27 | — | — | WO | disclosed |