Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733913 | 0.85 | TDP1 (0.37) | PDE4BL3MBTL1TDP1 | |
| SCHEMBL9733966 | 0.82 | ALDH1A1 (0.33) | PGRTSHRALDH1A1 | |
| SCHEMBL9733353 | 0.81 | CHRM1 (0.37) | L3MBTL1PGRCHRM1HPGDALDH1A1 | |
| SCHEMBL10433117 | 0.73 | ESR1 (0.34) | PDE4BL3MBTL1TDP1KDM4ETSHR | |
| SCHEMBL9733434 | 0.70 | SLC6A2 (0.39) | — | |
| SCHEMBL9733018 | 0.70 | HRH4 (0.34) | L3MBTL1PGRALDH1A1PPARGNPSR1 | |
| SCHEMBL9733195 | 0.68 | HRH4 (0.34) | — | |
| SCHEMBL9733614 | 0.68 | ALDH1A1 (0.35) | ALDH1A1RXFP1 | |
| SCHEMBL9734559 | 0.68 | RXFP1 (0.39) | L3MBTL1KDM4ETSHRALDH1A1PPARG | |
| SCHEMBL9733797 | 0.68 | MEN1 (0.40) | TDP1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |