SCHEMBL9735234

SCHEMBL9735234

CN(C)S(=O)(=O)n1cc(S(=O)(=O)N2CCc3ccccc3C2)nc1C#N

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.44
MEN1 O00255 4/20 0.44
AKR1C3 P42330 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
MAPK1 P28482 3/20 0.40
TSHR P16473 2/20 0.40
CYP2C19 P33261 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CYP3A4 P08684 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
LMNA P02545 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9735952 0.83 TSHR (0.50) KMT2AMEN1MAPK1TSHRSMN1; SMN2
SCHEMBL9736764 0.80 HTT (0.41) KMT2AMEN1MAPK1MAPTLMNA
SCHEMBL9736879 0.79 L3MBTL1 (0.44) KMT2AMEN1L3MBTL1MAPK1TSHR
SCHEMBL9845735 0.78 GAA (0.40) KMT2AMEN1MAPK1SMN1; SMN2NPSR1
SCHEMBL9876240 0.76 KDM4E (0.38) TSHRSMN1; SMN2NPSR1KDM4EMAPT
SCHEMBL9736151 0.75 LMNA (0.46) KMT2AMEN1L3MBTL1MAPK1TSHR
SCHEMBL9735045 0.74 KMT2A (0.49) KMT2AMEN1AKR1C3L3MBTL1MAPK1
SCHEMBL12754371 0.70 HSD11B1 (0.65) KMT2AMEN1KDM4EMAPT
SCHEMBL9521448 0.69 TSHR (0.46) KMT2AMEN1L3MBTL1MAPK1TSHR
SCHEMBL17227611 0.65 KMT2A (0.62) KMT2AMEN1AKR1C3L3MBTL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0432892-A1 Imidazole fungicides AgrEvo UK Limited (GB) 1991-06-19 EP claimed
JP-3170464-A None JP disclosed
US-5173503-A Derivatives of N,N-dimethyl-4-phenylalkylenesulfonyl-imidazole -1-sulphonamides; phytopathogenic fungi SCHERING AGROCHEMICALS LIMITED (GB) 1992-12-22 US disclosed
JP-H03170464-A IMIDAZOLE FUNGICIDE SCHERING AGROCHEM LTD 1991-07-24 JP disclosed
EP-0432892-A1 Imidazole fungicides AgrEvo UK Limited (GB) 1991-06-19 EP disclosed