Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 4/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656458 | 0.86 | ALOX5 (0.40) | ALOX5 | |
| SCHEMBL9736815 | 0.77 | NOTUM (0.56) | ALOX5PLA2G10 | |
| SCHEMBL9737137 | 0.70 | HTR2A (0.38) | HTR2AHTR2CMAT2A | |
| SCHEMBL13279458 | 0.63 | CCR9 (0.34) | HTR2AHTR2CKMO | |
| SCHEMBL17907979 | 0.62 | PTGDR2 (0.39) | HTR2AHTR2CKMO | |
| SCHEMBL9736001 | 0.62 | AHR (0.41) | HTR2AHTR2CAHRALOX5 | |
| SCHEMBL9535885 | 0.62 | TRPM8 (0.42) | — | |
| SCHEMBL9735956 | 0.59 | NOTUM (0.62) | HTR2AHTR2CMAT2AKMO | |
| SCHEMBL7972927 | 0.58 | ALOX5 (0.40) | ALOX5 | |
| SCHEMBL7972679 | 0.58 | ALOX5 (0.40) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |