SCHEMBL9738335

SCHEMBL9738335

CSc1cc(C(F)(F)F)nc(N(C(N)=O)c2c(Cl)cccc2Cl)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 3/20 0.39
ALDH1A1 P00352 2/20 0.36
HPGD P15428 1/20 0.36
NPSR1 Q6W5P4 1/20 0.35
LMNA P02545 1/20 0.33
CYP1A2 P05177 2/20 0.32
KMT2A Q03164 3/20 0.32
MEN1 O00255 2/20 0.32
GAA P10253 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PRKD3 O94806 1/20 0.32
CLK2 P49760 1/20 0.32
DYRK1A Q13627 1/20 0.32
PRKD2 Q9BZL6 1/20 0.32
PIM2 Q9P1W9 1/20 0.32
MAPT P10636 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
PDE4B Q07343 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9737076 0.85 MAPK14 (0.43) MAPK14ALDH1A1HPGDNPSR1LMNA
SCHEMBL9740354 0.80 MAPK14 (0.39) MAPK14ALDH1A1HPGDLMNAKMT2A
SCHEMBL9737104 0.79 LMNA (0.40) MAPK14ALDH1A1HPGDLMNAKMT2A
SCHEMBL9737369 0.79 MAPK14 (0.40) MAPK14ALDH1A1HPGDLMNAGAA
SCHEMBL9738360 0.79 MAPK14 (0.41) MAPK14LMNAGAAPRKD3CLK2
SCHEMBL9739327 0.75 SDHB (0.39) MAPK14ALDH1A1HPGDLMNAGAA
SCHEMBL9737747 0.74 PTGES (0.36) MAPK14NPSR1GAAMAPTPDE4B
SCHEMBL9739162 0.73 MAPK14 (0.38) MAPK14PRKD3CLK2DYRK1APRKD2
SCHEMBL10400150 0.73 MAPK14 (0.41) MAPK14LMNACYP1A2KMT2AMEN1
SCHEMBL9738307 0.73 LMNA (0.37) MAPK14ALDH1A1HPGDNPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5159078-A Herbicides, plant growth regulator CIBA-GEIGY CORPORATION (US) 1992-10-27 US disclosed
US-4966622-A HERBICIDES, PLANT GROWTH REGULATORS CIBA-GEIGY CORPORATION (US) 1990-10-30 US disclosed