SCHEMBL9739162

SCHEMBL9739162

NC(=O)N(c1nc(C2CC2)cc(C(F)(F)F)n1)c1c(F)cccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 3/20 0.38
CRACR2A Q9BSW2 9/20 0.37
TRPV1 Q8NER1 2/20 0.35
PRKD3 O94806 1/20 0.35
CLK2 P49760 1/20 0.35
DYRK1A Q13627 1/20 0.35
PRKD2 Q9BZL6 1/20 0.35
PIM2 Q9P1W9 1/20 0.35
HCRTR1 O43613 2/20 0.35
HCRTR2 O43614 2/20 0.35
TLR8 Q9NR97 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9737369 0.94 MAPK14 (0.40) MAPK14CRACR2ATRPV1TLR8
SCHEMBL9738360 0.83 MAPK14 (0.41) MAPK14PRKD3CLK2DYRK1APRKD2
SCHEMBL9737252 0.78 TLR8 (0.35) CRACR2ATRPV1HCRTR1HCRTR2TLR8
SCHEMBL9737076 0.76 MAPK14 (0.43) MAPK14
SCHEMBL9737730 0.76 TLR8 (0.35) CRACR2AHCRTR1HCRTR2TLR8
SCHEMBL9738579 0.74 PRKD3 (0.43) MAPK14PRKD3CLK2DYRK1APRKD2
SCHEMBL9740354 0.73 MAPK14 (0.39) MAPK14HCRTR1HCRTR2
SCHEMBL9738335 0.73 MAPK14 (0.39) MAPK14PRKD3CLK2DYRK1APRKD2
SCHEMBL9737104 0.72 LMNA (0.40) MAPK14
SCHEMBL9538973 0.71 SMN1; SMN2 (0.38) MAPK14PRKD3CLK2DYRK1APRKD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5159078-A Herbicides, plant growth regulator CIBA-GEIGY CORPORATION (US) 1992-10-27 US disclosed
US-4966622-A HERBICIDES, PLANT GROWTH REGULATORS CIBA-GEIGY CORPORATION (US) 1990-10-30 US disclosed