Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740303 | 0.93 | HRH3 (0.60) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9739552 | 0.92 | CHRNB2 (0.57) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9205099 | 0.89 | HRH3 (0.48) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9211609 | 0.86 | KDM4E (0.55) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9208504 | 0.86 | HRH2 (0.49) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9210505 | 0.81 | HRH3 (0.57) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9205156 | 0.80 | CHRNB2 (0.54) | HRH3CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL9212384 | 0.78 | ADRA1A (0.52) | KDM4EALDH1A1KMT2ADRD3 | |
| SCHEMBL9207731 | 0.76 | SIGMAR1 (0.43) | HRH3 | |
| SCHEMBL9740178 | 0.76 | HRH3 (0.48) | HRH3ALDH1A1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |