Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9741306 | 0.78 | ATM (0.47) | SMN1; SMN2ALDH1A1POLBMAPTTDP1 | |
| SCHEMBL8746025 | 0.77 | MAPT (0.37) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL9739624 | 0.77 | LMNA (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL9739644 | 0.77 | MAPT (0.38) | SMN1; SMN2ALDH1A1POLBMAPTTDP1 | |
| SCHEMBL9711233 | 0.73 | KDM4E (0.38) | SMN1; SMN2MAPTTDP1MAPK1KDM4E | |
| SCHEMBL9739776 | 0.73 | MTNR1A (0.51) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL778637 | 0.72 | BACE1 (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL4368896 | 0.71 | ALDH1A1 (0.48) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL9740858 | 0.70 | USP7 (0.42) | SMN1; SMN2ALDH1A1MAPTTDP1MAPK1 | |
| SCHEMBL30784461 | 0.70 | BACE1 (0.45) | SMN1; SMN2NPC1RAB9AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |