Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.55 |
| ▸ | MMP9 | P14780 | 13/20 | 0.55 |
| ▸ | MMP8 | P22894 | 13/20 | 0.55 |
| ▸ | REN | P00797 | 7/20 | 0.47 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.42 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | MMP15 | P51511 | 1/20 | 0.42 |
| ▸ | MMP16 | P51512 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.42 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.42 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740864 | 1.00 | MMP2 (0.55) | MMP2MMP9MMP8RENADAM10 | |
| SCHEMBL9741102 | 0.77 | MMP2 (0.57) | MMP2MMP9MMP8RENMMP1 | |
| SCHEMBL9739604 | 0.76 | MMP2 (0.51) | MMP2MMP9MMP8REN | |
| SCHEMBL9739605 | 0.76 | MMP2 (0.51) | MMP2MMP9MMP8REN | |
| SCHEMBL9740882 | 0.75 | MMP2 (0.54) | MMP2MMP9MMP8REN | |
| SCHEMBL9740887 | 0.75 | MMP2 (0.54) | MMP2MMP9MMP8REN | |
| SCHEMBL7269499 | 0.73 | REN (0.57) | REN | |
| SCHEMBL7269492 | 0.73 | REN (0.57) | REN | |
| SCHEMBL9740414 | 0.71 | REN (0.56) | REN | |
| SCHEMBL9739660 | 0.71 | REN (0.51) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | claimed |