Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9754030 | 0.82 | ALOX5 (0.44) | MEN1KMT2A | |
| SCHEMBL9754095 | 0.78 | LMNA (0.43) | MAPTALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL25146751 | 0.75 | LOXL2 (0.56) | MAPTCYP4A11CYP4F2LOXL2RAB9A | |
| SCHEMBL765010 | 0.74 | LOXL2 (0.61) | MAPTMEN1LMNAKMT2ACYP4A11 | |
| SCHEMBL27525241 | 0.70 | MAPT (0.59) | MAPTMEN1GAAKMT2ACYP4A11 | |
| SCHEMBL9754150 | 0.69 | ALOX5 (0.48) | MAPTKDM4EKMT2A | |
| SCHEMBL3234965 | 0.69 | MAPT (0.60) | MAPTCYP4A11CYP4F2SMN1; SMN2TP53 | |
| SCHEMBL10169575 | 0.69 | CYP4A11 (0.68) | MAPTALDH1A1MEN1LMNAGAA | |
| SCHEMBL8121457 | 0.66 | PTPN1 (0.55) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL9339199 | 0.66 | DHFR (0.54) | MAPTALDH1A1KDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |