Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 6/20 | 0.48 |
| ▸ | AURKA | O14965 | 6/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991589 | 0.83 | NPC1 (0.56) | METAP1METAP2AURKAFGFR1 | |
| SCHEMBL8777040 | 0.82 | METAP2 (0.51) | METAP1METAP2 | |
| SCHEMBL12833538 | 0.75 | KDM4E (0.68) | METAP1METAP2PDE5AAURKAHPSE | |
| SCHEMBL1170747 | 0.74 | METAP1 (0.72) | METAP1METAP2PDE5AAURKAHPSE | |
| SCHEMBL14091477 | 0.73 | PDE5A (0.62) | METAP1METAP2PDE5AAURKAHPSE | |
| SCHEMBL1385432 | 0.73 | ALDH1A1 (0.42) | METAP1 | |
| SCHEMBL9404099 | 0.73 | ADRA2A (0.44) | — | |
| SCHEMBL543150 | 0.71 | RAB9A (0.47) | AURKAFGFR1 | |
| SCHEMBL2320187 | 0.70 | KDM4E (0.47) | METAP1METAP2 | |
| SCHEMBL7456059 | 0.70 | AURKA (0.64) | METAP1METAP2PDE5AAURKAHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066652-A | ANTIULCER AGENTS | CHIESI FARMACEUTICI S.P.A. (IT) | 1991-11-19 | — | — | US | disclosed |