Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.32 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 4/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.30 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.30 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9764009 | 1.00 | MTNR1A (0.33) | MTNR1AMTNR1BMEN1KMT2AHTT | |
| Fumaric Acid SCHEMBL9549925 | 0.84 | MEN1 (0.41) | MTNR1AMTNR1BMEN1KMT2AHTT | |
| Fumaric Acid SCHEMBL9549905 | 0.84 | MEN1 (0.41) | MTNR1AMTNR1BMEN1KMT2AHTT | |
| SCHEMBL9549943 | 0.81 | MTNR1A (0.42) | MTNR1AMTNR1BMEN1KMT2AHTT | |
| SCHEMBL9764582 | 0.78 | OPRM1 (0.38) | MTNR1AMTNR1B | |
| SCHEMBL9549902 | 0.66 | LMNA (0.46) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 | |
| SCHEMBL9549963 | 0.66 | MTNR1A (0.44) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL9549917 | 0.64 | LMNA (0.48) | MTNR1AMTNR1BMEN1KMT2AALDH1A1 | |
| SCHEMBL9549959 | 0.64 | LMNA (0.47) | MTNR1AL3MBTL1ALDH1A1NQO2 | |
| SCHEMBL9549926 | 0.62 | SIGMAR1 (0.47) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5010083-A | Cognition activator; Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-23 | — | — | US | disclosed |