Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA known ✓ | P10827 | 1/20 | 0.44 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407331 | 0.85 | KMT2A (0.60) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL28823470 | 0.84 | KMT2A (0.54) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL14672405 | 0.84 | PLA2G4B (0.59) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL9764089 | 0.84 | KMT2A (0.56) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL11761650 | 0.84 | KMT2A (0.54) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL9716543 | 0.84 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL17138195 | 0.84 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL17138156 | 0.84 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL17138196 | 0.84 | KMT2A (0.61) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPK1 | |
| SCHEMBL9764075 | 0.82 | KMT2A (0.53) | KMT2ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1306498-A | — | — | None | — | — | JP | disclosed |
| US-5002687-A | Acyloxybenzoic Acid Bleach Precursor | LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) | 1991-03-26 | — | — | US | disclosed |
| JP-H01306498-A | CLOTH WASHING COMPOSITION | UNILEVER NV | 1989-12-11 | — | — | JP | disclosed |
| EP-0337274-A2 | Fabric-washing compositions | UNILEVER N.V. (NL) | 1989-10-18 | — | — | EP | disclosed |