SCHEMBL9765814

SCHEMBL9765814

O=c1cc(C(F)(F)F)ncn1-c1ncc(C(F)(F)F)cc1Cl

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
POLB P06746 1/20 0.47
MAPT P10636 2/20 0.46
TDP1 Q9NUW8 1/20 0.44
GAA P10253 2/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
NPSR1 Q6W5P4 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HTT P42858 1/20 0.43
ATM Q13315 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
LMNA P02545 1/20 0.43
PKM P14618 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9765875 0.83 ALDH1A1 (0.36) ALDH1A1POLBMAPTTDP1GAA
SCHEMBL9723106 0.81 GABRA2 (0.40) MEN1KMT2ANPSR1LMNAL3MBTL1
SCHEMBL9683010 0.81 ALDH1A1 (0.49) ALDH1A1POLBMAPTTDP1GAA
SCHEMBL9765847 0.80 GAA (0.39) ALDH1A1MAPTTDP1GAAMEN1
SCHEMBL10701517 0.80 ALDH1A1 (0.51) ALDH1A1POLBMAPTTDP1GAA
SCHEMBL9765906 0.79 ALDH1A1 (0.39) ALDH1A1POLBMAPTTDP1GAA
SCHEMBL10700184 0.79 ALDH1A1 (0.50) ALDH1A1POLBMAPTTDP1GAA
SCHEMBL10457648 0.79 ALDH1A1 (0.56) ALDH1A1POLBMAPTGAAMEN1
SCHEMBL9723104 0.77 GABRA2 (0.37) ALDH1A1MAPTMEN1KMT2ANPSR1
SCHEMBL9340316 0.77 GABRA2 (0.37) GAAMEN1KMT2ANPSR1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3483144-B1 HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD CONTROLLING AGENT CONTAINING SAME SUMITOMO CHEMICAL CO (JP) 2023-10-11 EP disclosed
US-20190327970-A1 HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD CONTROLLING AGENT CONTAINING SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2019-10-31 US disclosed
US-4990512-A Insecticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190327970-A1 HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD CONTROLLING AGENT CONTAINING SAME DDT, ACHE, NISCH ALDH1A1 776/4885POLB 4172/4885MAPT 4119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.