Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768754 | 0.85 | NR1I3 (0.43) | MTNR1AMTNR1BSLC6A2CA2CA9 | |
| SCHEMBL9768739 | 0.85 | GRM7 (0.38) | MTNR1AMTNR1BSLC6A2CA2CA9 | |
| SCHEMBL9768785 | 0.83 | NPC1 (0.53) | CA2CA9TP53CYP2C9HSD11B1 | |
| SCHEMBL9768706 | 0.81 | MAPT (0.44) | SLC6A2CA2CA9TP53MAPT | |
| SCHEMBL9768762 | 0.81 | NPC1 (0.40) | SLC6A3CA2CA9TP53MAPT | |
| SCHEMBL9768740 | 0.78 | CYP2D6 (0.53) | TP53MAPTCYP2C9CYP3A4KMT2A | |
| SCHEMBL9768744 | 0.78 | NR1I3 (0.44) | TP53MAPTPOLBGAA | |
| SCHEMBL9768831 | 0.78 | ALDH1A1 (0.56) | TP53MAPTPOLBMEN1CYP3A4 | |
| SCHEMBL9768823 | 0.78 | KDM4E (0.46) | CA2CA9TP53MAPTPOLB | |
| SCHEMBL9768805 | 0.78 | LMNA (0.46) | CA2CA9TP53MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | disclosed |
| EP-0354885-A1 | Novel derivatives of 6,11-dihydro-dibenzo[c,f][1,2,5]-thiadiazepine 5,5-dioxide, salts thereof and appropriate processes for the preparation thereof | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1990-02-14 | — | — | EP | disclosed |