Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768785 | 0.80 | NPC1 (0.53) | CA2CA9ALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL9768832 | 0.78 | MTNR1A (0.40) | CA2CA9MEN1CYP3A4KMT2A | |
| SCHEMBL9768762 | 0.78 | NPC1 (0.40) | LMNABCHECA2CA9MEN1 | |
| SCHEMBL9768706 | 0.78 | MAPT (0.44) | CA2CA9KMT2AKDM4EALDH1A1 | |
| SCHEMBL3296716 | 0.76 | TSHR (0.71) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL9768831 | 0.76 | ALDH1A1 (0.56) | MEN1CYP3A4KMT2AKDM4EALDH1A1 | |
| SCHEMBL9768823 | 0.76 | KDM4E (0.46) | LMNABCHECA2CA9MEN1 | |
| SCHEMBL9768744 | 0.76 | NR1I3 (0.44) | TSHRKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL9768740 | 0.76 | CYP2D6 (0.53) | LMNATSHRCYP3A4KMT2AKDM4E | |
| SCHEMBL9768754 | 0.75 | NR1I3 (0.43) | BCHECA2CA9MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011833-A | Antidepressant | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE (IT) | 1991-04-30 | — | — | US | disclosed |
| EP-0354885-A1 | Novel derivatives of 6,11-dihydro-dibenzo[c,f][1,2,5]-thiadiazepine 5,5-dioxide, salts thereof and appropriate processes for the preparation thereof | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1990-02-14 | — | — | EP | disclosed |