Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Enrofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG known ✓ | P48736 | 5/20 | 0.61 |
| ▸ | PIK3CD known ✓ | O00329 | 3/20 | 0.61 |
| ▸ | PIK3R1 known ✓ | P27986 | 3/20 | 0.61 |
| ▸ | PIK3CA known ✓ | P42336 | 3/20 | 0.61 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | HPGD | P15428 | 2/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 0.98 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | TOP2A | P11388 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enrofloxacin SCHEMBL9788077 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL27727004 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL28552869 | 0.99 | KDM4E (0.96) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL6742652 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL149150 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL17554684 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL29349852 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL16784595 | 0.98 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL10741694 | 0.98 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| Enrofloxacin SCHEMBL8027963 | 0.98 | KDM4E (0.98) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103830240-B | A kind of flouroquinolone drugs compositions | 洛阳惠中兽药有限公司 | 2016-07-06 | — | — | CN | claimed |
| CN-103830240-A | Fluoroquinolone medicine composition | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2014-06-04 | — | — | CN | claimed |
| CN-103816544-A | Composition containing enrofloxacin hexahydrate and application of same in preparation of drugs used for treating or preventing diseases of domestic animals | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2014-05-28 | — | — | CN | claimed |
| CN-101961335-B | Enrofloxacin hexahydrate-containing composition and application thereof in preparation of medicines for treating or preventing poultry diseases | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2012-04-25 | — | — | CN | claimed |
| CN-101961335-A | Enrofloxacin hexahydrate-containing composition and application thereof in preparing medicament for treating or preventing poultry diseases | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2011-02-02 | — | — | CN | claimed |
| US-20110003829-A1 | ENROFLOXACIN HEXAHYDRATE | BAYER ANIMAL HEALTH GMBH (DE) | 2011-01-06 | — | — | US | claimed |
| CN-101933927-A | Enrofloxacin hexahydrate-containing composition and application thereof in preparation of medicines for treating or preventing diseases of livestock | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2011-01-05 | — | — | CN | claimed |
| CN-103830240-B | A kind of flouroquinolone drugs compositions | 洛阳惠中兽药有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-103211818-B | Pharmaceutical composition for treating or preventing bacterial and mycoplasma diseases of livestock and use thereof | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2015-07-22 | — | — | CN | disclosed |
| CN-103830240-A | Fluoroquinolone medicine composition | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2014-06-04 | — | — | CN | disclosed |
| CN-103816544-A | Composition containing enrofloxacin hexahydrate and application of same in preparation of drugs used for treating or preventing diseases of domestic animals | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2014-05-28 | — | — | CN | disclosed |
| CN-103816544-A | Composition containing enrofloxacin hexahydrate and application of same in preparation of drugs used for treating or preventing diseases of domestic animals | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2014-05-28 | — | — | CN | disclosed |
| CN-103816544-A | Composition containing enrofloxacin hexahydrate and application of same in preparation of drugs used for treating or preventing diseases of domestic animals | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2014-05-28 | — | — | CN | disclosed |
| CN-103211818-A | Pharmaceutical composition for treating or preventing bacterial and mycoplasma diseases of livestock and use thereof | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2013-07-24 | — | — | CN | disclosed |
| CN-101961335-B | Enrofloxacin hexahydrate-containing composition and application thereof in preparation of medicines for treating or preventing poultry diseases | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2012-04-25 | — | — | CN | disclosed |
| CN-101961335-A | Enrofloxacin hexahydrate-containing composition and application thereof in preparing medicament for treating or preventing poultry diseases | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2011-02-02 | — | — | CN | disclosed |
| US-20110003829-A1 | ENROFLOXACIN HEXAHYDRATE | BAYER ANIMAL HEALTH GMBH (DE) | 2011-01-06 | — | — | US | disclosed |
| CN-101933927-A | Enrofloxacin hexahydrate-containing composition and application thereof in preparation of medicines for treating or preventing diseases of livestock | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2011-01-05 | — | — | CN | disclosed |
| CN-101933927-A | Enrofloxacin hexahydrate-containing composition and application thereof in preparation of medicines for treating or preventing diseases of livestock | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2011-01-05 | — | — | CN | disclosed |
| CN-101933927-A | Enrofloxacin hexahydrate-containing composition and application thereof in preparation of medicines for treating or preventing diseases of livestock | LUOYANG HUIZHONG ANIMAL MEDICINE CO LTD | 2011-01-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003829-A1 | ENROFLOXACIN HEXAHYDRATE | TRAF6, QRFPR, RTRAF | PIK3CG 3924/4885PIK3CD 3841/4885PIK3R1 2744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.