Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877089 | 0.83 | MEN1 (0.56) | HPGDSCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL9787284 | 0.79 | HPGD (0.43) | HPGDSCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL7438756 | 0.73 | ALDH1A1 (0.45) | CES2CES1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL182010 | 0.71 | CES2 (0.71) | HPGDSCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL9787285 | 0.70 | HPGDS (0.46) | HPGDSCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL9787264 | 0.69 | LMNA (0.47) | ALDH1A1ALOX15HSD17B10MMP2MAPT | |
| SCHEMBL10806120 | 0.69 | ALDH1A1 (0.49) | HPGDSCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL9787344 | 0.69 | ALDH1A1 (0.46) | CES2CES1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL9787252 | 0.68 | PDE4A (0.45) | CES2CES1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL9787361 | 0.68 | PDE4A (0.45) | CES2CES1ALOX15HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999365-A | Preventing damage which occurs to heart tissue when oxygen is reintroduced after a heart attack | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-12 | — | — | US | disclosed |